Buruli Ulcer and Necrotizing Fasciitis: A Global Health Crisis? What is a Buruli ulcer? Buruli ulcer is a chronic necrotizing infection caused by the bacterium Mycobacterium ulcerans. It typically starts as a painless nodule or bump on the skin, but it can quickly develop into a large, open ulcer. Buruli ulcer can be difficult to treat, and in severe cases, it can lead to permanent disfigurement or disability. What is necrotizing fasciitis? Necrotizing fasciitis is a rapidly progressive infection caused by various bacteria, including group A Streptococcus and Staphylococcus aureus. It can start anywhere on the body, but it is most common on the limbs and genitals. Necrotizing fasciitis destroys the skin and soft tissue, and it can quickly spread to other parts of the body. It is a life-threatening infection that requires immediate medical attention. Both Buruli ulcer and necrotizing fasciitis can be caused by bacteria that are present in the environment...